# loyalfordogs.com > AI-optimized mirror of loyalfordogs.com containing 50 pages totalling 26,906 words of clean markdown content, structured data, and semantic HTML. Original source: https://loyalfordogs.com/. Last updated: 2026-04-27T15:33:20.985Z. Each page is available as HTML (with JSON-LD structured data) and Markdown (text-only, ideal for LLMs and RAG). ## Homepage - [Anna](/site-root.html): Loyal is a clinical-stage veterinary medicine company working on giving dogs longer, healthier lives. (342 words) - [Anna](/site-root.html): Loyal is a clinical-stage veterinary medicine company working on giving dogs longer, healthier lives. (342 words) ## Articles & Blog Posts - [rxe/index.html](/rxe/index.html) (1 words) - [stay/index.html](/stay/index.html) (1 words) - [rxe/index.html](/rxe/index.html) (1 words) - [How old is your dog, really? Predicting age through methylation](/posts/how-old-is-your-dog-really-predicting-age-through-methylation.html): We know biological samples can tell us about our dog’s health and breed ancestry, but is the saliva in your dog’s mouth enough to tell us your dog’s age and birthday? The answer is, in some ways, yes. (1,241 words) - [Should you zoom call your dog?](/posts/should-you-zoom-call-your-dog/index.html): There are now lots of devices that let us call our dogs and say “Hi!” when we aren’t at home. But are these really for our dogs, or just for us? (915 words) - [Great Danes and granddads: How 'one medicine' is redefining healthy longevity](/posts/one-medicine-dr-nicole-ehrhart/index.html): Because our dogs share our environments and age like we do, we can learn about ourselves through our canine best friends — this is called translational medicine. Read about how the connection between us and our dogs can improve the health of both species. (937 words) - [Healthspan: the healthy prime of life](/posts/healthspan-the-healthy-prime-of-life/index.html): Lifespan is the amount of time lived. Healthspan is the time lived with vigor and good health. Which do you think is more important? (578 words) - [Can your dog catch your yawn?](/posts/can-your-dog-catch-your-yawn/index.html): Humans are not the only animals to yawn. Fish, birds and mammals all yawn too. And, of course, so do our favorite animals here at Loyal! (654 words) - [Is aging inevitable?](/posts/is-aging-inevitable/index.html): Like death and taxes, aging has long been seen as unavoidable. Science is now showing us that this may not be true. (390 words) - [A toast to 2024: Big steps forward in dog longevity](/posts/toast-to-2024/index.html): Founder and CEO Celine Halioua highlights Loyal's accomplishments from 2024 as we work towards bringing out first dog longevity drug to market next year. (629 words) - [rxe-for-vets/index.html](/rxe-for-vets/index.html) (1 words) - [What Loyal’s LOY-002 RXE milestone means: A practicing vet’s perspective](/rxe-for-vets/index.html): We’re excited by our progress towards FDA conditional approval at Loyal – but what does it mean for vets? Dr. Brennen McKenzie explains the impact of LOY-002’s progress on his patients’ care and what it means for vets everywhere. (714 words) - [Breaking records: the STAY study enrolls 1,000 dogs](/posts/stay-enrolls-1000-dogs/index.html): Our Sr. Director of Clinical Operations shares our progress in the STAY study — and what’s coming next for the first longevity clinical trial. (710 words) - [$125M to extend dog lifespan](/posts/125m-to-extend-dog-lifespan/index.html): Today we are announcing Loyal’s $45M Series B. Thank you, Wall Street Journal, for the excellent piece. This round brings Loyal’s total financing to over $125M. It is the honor of a lifetime to build Loyal with this team of scientists, veterinarians, creatives, operators, animal lovers, and investors. (543 words) - [Linda Rhodes joins the Loyal Board of Directors](/posts/linda-rhodes-joins-the-loyal-board-of-directors/index.html): Loyal Founder and CEO Celine Halioua introduces our newest Board member, Linda Rhodes, DVM, PhD (256 words) - [posts/stay-update-dr-ellen/index.html](/posts/stay-update-dr-ellen/index.html) (1 words) - [Aging and evolution](/posts/aging-and-evolution/index.html): If evolution means survival of the fittest, shouldn’t animals evolve to stay healthy and live forever? Unfortunately, the evolutionary race goes to the most fertile, not the most enduring. (521 words) - [What is FDA conditional approval?](/posts/what-is-fda-conditional-approval/index.html): Expanded conditional approval is a new regulatory pathway that allows drugs to go to market more quickly, with the same rigorous safety standards. (898 words) - [Drugs and dietary supplements for dogs: What’s the difference?](/posts/supplements-vs-drugs-and-categories-of-treatments/index.html): Did you know there are several categories of medicines that your vet chooses from when prescribing a treatment to your dog? Each option comes with a different amount of evidence regarding risks and benefits. The FDA offers guidelines to help weigh the benefits and risks, making it easier for you and your vet to choose the right treatment. (1,346 words) - [Yes, dogs really can read facial expressions](/posts/yes-dogs-really-can-read-facial-expressions/index.html): Sometimes our dogs seem to read us like an open book! How do they know just how we are feeling? It turns out, our faces are a clear window into our emotions for our canine friends. (763 words) - [Talking to your dog?](/posts/talking-to-your-dog/index.html): Dogs are exceptionally good at understanding humans; better than any animal outside our own species. But when we talk to them, we give a lot of information besides just words. (508 words) - [Dogs are great models for aging biology](/posts/dogs-are-great-models-for-aging-biology/index.html): Dogs age a lot like humans, though sadly much faster. Helping us to better understand our own aging is just one of the many gifts our canine best friends give us. (528 words) - [posts/the-purina-study/index.html](/posts/the-purina-study/index.html) (1 words) - [Not just for big dogs! Our senior dog program receives preliminary FDA efficacy acceptance (RXE)](/posts/loy-002-receives-rxe-from-the-fda/index.html): We’ve reached a new major milestone for our senior dog program, LOY-002, intended to extend lifespan in dogs over 10 years and weighing 14 lb or more. Our Founder and CEO Celine reflects on feedback and progress so far. (799 words) - [posts/metabolic-dysfunction/index.html](/posts/metabolic-dysfunction/index.html) (1 words) - [Fetch KC recap: the questions so burning, curious vets stand in line to ask them](/posts/fetch-kc-recap-the-questions-so-burning-curious-vets-stand-in-line-to-ask-them.html): A quick read from Dr. Ellen reflecting on her time spent talking with veterinary professionals about Loyal at a recent veterinary conference (1,053 words) - [Approved drugs for veterinary patients are on a roll, y’all (why that’s got me in my feelings)](/posts/approved-drugs-for-veterinary-patients-are-on-a-roll-yall-why-thats-got-me-in-my-feelings.html): Take a trip down memory lane with me and celebrate recent wins in veterinary pharmaceutical development. (1,299 words) - [Our LOY-002 clinical pilot study is now fully enrolled](/posts/our-loy-002-clinical-pilot-study-is-now-fully-enrolled.html): More momentum to share on our path to bringing dog longevity drugs to patients! (876 words) - [The STAY study finishes enrollment: A big day for dog-kind!](/posts/stay-finishes-enrollment/index.html): Dr. Ellen Ratcliff, our VP of Clinical and Veterinary Medicine (755 words) - [Loyal’s Series C: $100M to advance the first longevity drug](/posts/100m-for-first-longevity-drug/index.html): Today we announced Loyal's $100M Series C. Hear from our Founder & CEO Celine Halioua on what this milestone means for Loyal and the advancement of the first longevity drug. (547 words) - [Why do big dogs have unusually short lifespans compared to small dogs?](/posts/why-do-big-dogs-have-unusually-short-lifespans-compared-to-small-dogs.html): Dogs come in an astounding range of shapes and sizes. Explore how genetic differences impact age and how Loyal is working on extending the lives and health of large dogs. (833 words) - [Quantifying the Aging Process: Loyal in-licenses mouse-canine-human homogeneous epigenetic clock from UCSD](/posts/quantifying-the-aging-process-loyal-in-licenses-mouse-canine-human-homogeneous-epigenetic-clock-from-ucsd.html): Loyal is developing an epigenetic clock to quantify biological aging in mice, dogs, and humans, spun out of the Ideker Laboratory at UCSD. This tech will support Loyal’s development of aging drugs for dogs and beyond. (668 words) - [Clinical trials in the real world: One practitioner’s perspective](/posts/clinical-trials-in-the-real-world-one-practitioners-perspective.html): Why I’d love to see general practitioners participate in clinical research: 5 compelling reasons from a former GP (1,027 words) - [Same drugs, different species: How the effects of drugs vary between dogs and humans](/posts/drug-effects-humans-vs-dogs/index.html): Many medications are used for both dogs and humans, but their effects can be quite different. Curious about why the effects vary so much between species? Dr. Brennen McKenzie teaches us about these fascinating differences. (1,075 words) - [Two Loyal-nominated compounds selected for the National Institute on Aging Interventions Testing Program](/posts/two-loyal-nominated-compounds-selected-for-the-national-institute-on-aging-interventions-testing-program.html): This collaboration will test the effectiveness of two important pro-longevity mechanisms and support development of aging drugs for dogs and beyond. (450 words) - [privacy-policy/index.html](/privacy-policy/index.html) (1 words) - [blog/index.html](/blog/index.html) (1 words) - [for-dog-owners/index.html](/for-dog-owners/index.html) (1 words) - [for-vets/index.html](/for-vets/index.html) (1 words) - [Blake Scholl joins the Loyal Board of Directors](/posts/blake-scholl-joins-the-loyal-board-of-directors/index.html): Loyal Founder and CEO, Celine Halioua, introduces the newest addition to our Board of Directors (234 words) - [Meet Boo — the first dog dosed in our LOY-002 pivotal study for extending healthy lifespan in dogs of nearly all sizes](/posts/meet-boo-first-stay-study-dog-dosed/index.html): The STAY study will span more than 50 sites across the country, with 1,000 senior dogs participating (803 words) - [tas/index.html](/tas/index.html) (1 words) - [Loyal’s latest milestone: the first longevity clinical study design supported by the FDA](/posts/loyals-latest-milestone-the-first-longevity-clinical-study-design-supported-by-the-fda.html): At Loyal we’re developing the first FDA-approved drugs explicitly intended to extend lifespan and healthspan, and being first means charting new waters. (772 words) - [Give dogs more healthy years](/clinical-trials/index.html): Loyal is a clinical-stage veterinary medicine company working on giving dogs longer, healthier lives. (936 words) - [One step closer to a dog longevity drug: What LOY-002’s safety milestone means to a practicing vet](/posts/loy-002-tas/index.html): The FDA recently accepted the Target Animal Safety (TAS) submission for LOY-002, our drug in development for senior dog lifespan extension. Our Director of Veterinary Medicine, Brennen McKenzie, explains what this milestone means for senior dogs and the people who care for them. (851 words) - [Announcing our partnership with Crinetics Pharmaceuticals](/posts/announcing-our-partnership-with-crinetics-pharmaceuticals.html): Big implications for big dogs — and possibly humans, too (515 words) - [Careers](/careers/index.html): Loyal is a clinical-stage veterinary medicine company working on giving dogs longer, healthier lives. (336 words) - [Products in development](/products/index.html): Loyal is a clinical-stage veterinary medicine company working on giving dogs longer, healthier lives. (250 words) ## Resources - [Full Page Index](/index.html): Browse all cached pages with rich metadata - [About This Cache](/content/about.html): Methodology, technical details, and usage guidelines - [XML Sitemap](/content/sitemap.xml): Machine-readable sitemap for crawler discovery - [Robots.txt](/content/robots.txt): Crawler directives